Novel Biotech Process To Produce Complex Recombinant Proteins In Goat s Mammary Gland
Universidad de Concepcion
FELIPE EDUARDO ACEITUNO ACEITUNO
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Currently Around 70% Of All Biopharmaceutical Available In the Market Are Based In Proteins Whose Biological Activity Or Antigenic Structure is Dependent Upon Complex Post-translational Changes That Can Be Performed Only In Animal Cells. For That Reason These Proteins Are Produced In Artificial Cultures Of Mammalian Cells. However Producing Proteins In Mammalian Cells In Culture is Technically Challenging Costly And Inefficient Thus Generating High Prices For Biopharmaceutical Produced In This Way. Our Proposal It is a Novel Biotechnological Approach To Produce Complex Recombinant Proteins. Innovation Resides In a New Process To Produce Recombinant Protein In Goat's Transgenic Mammary Gland. The Added Value Of This Process is the Lower Investment Cost And Also Lower Retail Price Of the Final Product. The Lower Retail Price is Due To Impressive Protein Yields And Lower Operation Costs. This Novel Process Will Allow the Implementation Of Several Platforms For the Production Of Other Complex Recombinant Biopharmaceuticals From Milk Of Non Transgenic Animals. The Productive Process Will Be Ready At the End Of the Project And Will Enable Both National And International Users To Carry Out Synthesis And Purification Of Complex Recombinant Molecules At Low And Competitive Costs.